Organic contaminants in food and environment linked to diabetes

Organic contaminants in food and environment linked to diabetes

Июль 3, 2022 0 Автор science

The University of Oslo revealed an increased content of dioxins in the blood of patients with diabetes

Organochlorine contaminants in food, even at low concentrations, can cause type 1 diabetes. This conclusion was reached by scientists at the University of Oslo, who showed that certain chemicals, including dioxins, can disrupt insulin production and cause autoimmune disease. The results of the study are published in the journal Environment International.

Experts analyzed blood samples from 442 American children and adolescents. 182 people were diagnosed with type 1 diabetes with normal insulin sensitivity, 148 with type 1 diabetes with insulin resistance, and 112 healthy people were included in the control group. The concentrations of polychlorinated biphenyls (PCBs) and various organochlorine pesticides in blood plasma were used to assess the risk of developing autoimmune diabetes. The researchers also conducted an experiment in which rat pancreatic beta cells were exposed to biphenyl and dichlorodiphenyldichloroethylene (DDE) solutions at doses comparable to their elevated levels in the environment.

Scientists have found an association between plasma concentrations of contaminants such as DDE, trans-nonachlor and PCBs and the likelihood of being diagnosed with type 1 diabetes with normal insulin sensitivity. This association was not observed for patients with insulin resistance on the background of diabetes. In experiments, PCBs and DDE interfered with the ability of beta cells to produce and secrete insulin in response to glucose. This was accompanied by changes in the expression of various genes that were sensitive to pollutants, and prolonged exposure lasting more than two days gradually killed the cells.

PCBs and various organochlorines are found in food, plastics, paints, building materials, soil and water and are only slightly degraded naturally. Chlorine-containing pesticides continue to be used in a number of countries to control insect pests. At the same time, 90 percent of pollutants enter the body from meat, fish and dairy products. Experts recommend eating lean fish such as saithe, cod and haddock as it contains less dioxins and PCBs.