Antibody resistance of new strains of coronavirus explained

Antibody resistance of new strains of coronavirus explained

Июль 3, 2022 0 Автор science

SARS-CoV-2 antibody resistance triple mutation discovered at the University of Colorado

Scientists at the University of Colorado studied the effect of multiple mutations on the properties of various variants of the coronavirus. The results of the study helped explain the reasons for the resistance of new strains of SARS-CoV-2 to antibody treatment. This was reported in a press release on MedicalXpress.

The researchers showed that certain mutations appear repeatedly in new strains of SARS-CoV-2, demonstrating convergent evolution, in which similar traits appear independently in different groups of organisms. A similar process affected three amino acid positions K417, E484 and N501 in the receptor-binding domain of the spike protein (S-protein). Although individual mutations have both beneficial and detrimental effects, together they improve the adaptive properties of the virus.

The K417T mutation promotes the avoidance of class 1 antibodies, increases the stability and expression of the S protein, but it reduces the binding of the protein to the ACE2 receptor. E484K helps elude class 2 antibodies, however it reduces receptor binding, stability and expression. N501Y increases receptor binding but decreases stability and expression. The triple mutant K417T/E484K/N501Y has increased binding to the ACE2 receptor, avoids both class 1 and class 2 antibodies, and has the same stability and expression as the wild-type coronavirus.